本文由小咖机器人翻译整理

期刊来源：Ann Intern Med

原文链接：https://doi.org/10.7326/M23-3132

摘要内容如下：

背景

在许多研究中，限时进食（TRE）可以降低体重。正如在啮齿类动物的研究中所看到的，TRE是否独立于热量摄入的减少而诱导体重减轻尚不清楚。

客观

确定在稳定热量摄入的情况下，TRE与常规饮食模式（UEP）对体重的影响。

设计

随机、等热量喂养研究。（ClinicalTrials.gov：NCT03527368）

设置

临床研究单位。

参与者

患有肥胖症和前驱糖尿病或饮食控制糖尿病的成年人。

干预

参与者按1:1的比例被随机分配到TRE（10小时进食窗口，下午1点前摄入80%的卡路里）或UEP（≤16小时窗口，下午5点后摄入≥50%的卡路里），为期12周。两组的营养成分相同，热量相同，总热量在基线时确定。

测量

主要结果是12周时体重的变化。次要转归为空腹血糖、胰岛素抵抗稳态模型评估（HOMA-IR）、口服葡萄糖耐量试验的葡萄糖曲线下面积和糖化白蛋白。我们使用线性混合模型来评估干预措施对结果的影响。

结果

所有41名随机分配的参与者（平均年龄59岁；93%为女性；93%为黑人；平均BMI，36 kg/m2）完成干预。TRE组的基线体重为95.6 kg（95%CI，89.6至101.6 kg），UEP组的基线体重为103.7 kg（95.3至112.0 kg）。12周时，TRE组体重下降2.3 kg（CI，1.0至3.5 kg），UEP组体重下降2.6 kg（CI，1.5至3.7 kg）（TRE与UEP的平均差异为0.3 kg[CI，-1.2至1.9 kg]）。血糖指标的变化在两组之间没有差异。

局限性

小型单点研究；各组体重的基线差异。

结论

在等热量饮食的情况下，相对于UEP，TRE没有降低体重或改善葡萄糖稳态，这表明在先前的研究中，TRE对体重的任何影响可能是由于热量摄入的减少。

主要资金来源

美国心脏协会。

英文原文如下：

Abstracts

BACKGROUND  Time-restricted eating (TRE) lowers body weight in many studies. Whether TRE induces weight loss independent of reductions in calorie intake, as seen in rodent studies, is unknown.

OBJECTIVE  To determine the effect of TRE versus a usual eating pattern (UEP) on body weight in the setting of stable caloric intake.

DESIGN  Randomized, isocaloric feeding study. (ClinicalTrials.gov: NCT03527368).

SETTING  Clinical research unit.

PARTICIPANTS  Adults with obesity and prediabetes or diet-controlled diabetes.

INTERVENTION  Participants were randomly assigned 1:1 to TRE (10-hour eating window, 80% of calories before 1 p.m.) or UEP (≤16-hour window, ≥50% of calories after 5 p.m.) for 12 weeks. Both groups had the same nutrient content and were isocaloric with total calories determined at baseline.

MEASUREMENTS  Primary outcome was change in body weight at 12 weeks. Secondary outcomes were fasting glucose, homeostatic model assessment for insulin resistance (HOMA-IR), glucose area under the curve by oral glucose tolerance test, and glycated albumin. We used linear mixed models to evaluate the effect of interventions on outcomes.

RESULTS  All 41 randomly assigned participants (mean age, 59 years; 93% women; 93% Black race; mean BMI, 36 kg/m2) completed the intervention. Baseline weight was 95.6 kg (95% CI, 89.6 to 101.6 kg) in the TRE group and 103.7 kg (CI, 95.3 to 112.0 kg) in the UEP group. At 12 weeks, weight decreased by 2.3 kg (CI, 1.0 to 3.5 kg) in the TRE group and by 2.6 kg (CI, 1.5 to 3.7 kg) in the UEP group (average difference TRE vs. UEP, 0.3 kg [CI, -1.2 to 1.9 kg]). Change in glycemic measures did not differ between groups.

LIMITATION  Small, single-site study; baseline differences in weight by group.

CONCLUSION  In the setting of isocaloric eating, TRE did not decrease weight or improve glucose homeostasis relative to a UEP, suggesting that any effects of TRE on weight in prior studies may be due to reductions in caloric intake.

PRIMARY FUNDING SOURCE  American Heart Association.

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